How to Reduce the Complexity of Single-Use Systems


Five Key Benefits of Genderless Aseptic Connectors:

Traditionally, single-use connections would consist of a different male half and female half, that are mated with each other. These are called gendered connections. Genderless connections are those in which the connector halves are identical in design, eliminating the need for a different male and female half to make the connection, providing end users with maximum flexibility.

1. Fewer custom designs

Complex bioprocesses often suffer from a proliferation of custom single-use system (SUS) designs, with a dedicated SUS for each unit operation and process volume. Several case studies have shown that with a modular approach and the implementation of genderless aseptic connectors, the total number of custom SUS to support the same process, could be reduced by 75%.

2. Genderless connectors enable standardization

Through a modular implementation approach that leverages genderless aseptic connectors, standard bag and transfer set designs may be implemented, allowing for standard bag designs with a common connection, designated only by volume. Filter sets with different filtration areas and functions and tube transfer sets can then be used to configure the system design required for each unit operation. The inherent flexibility of this approach may enable a more flexible response to interruptions within the single-use supply chain. One downside of modular systems is the reduced ability to error-proof the SUS design. Additional procedural controls must be implemented to prevent errors during assembly and use.

3. Reduced number of items to manage through the supply chain

Genderless connectors cut the number of items to be managed through the supply chain by 50%. The supply chain issues of 2021 clearly show that simplicity within the supply chain and consolidation of the total number of items to be managed can positively impact on the efficiency of inventories and the overall resiliency of the supply chain.

4. Genderless connectors are designed for manufacturing

In addition to allowing more efficient inventories, genderless connectors reduce by half, the number of items to be produced, and by significantly more than half the number of molded parts used to produce the finished connectors. Secondary operations are reduced and simplified making genderless connectors more efficient to produce and faster to scale up manufacturing during surges in demand.

5. Genderless connectors lower costs

Genderless connectors create efficiencies that reduce the total cost of ownership of the SUS that employ them: Reduced direct connector costs, more efficient inventories, reduced number of SUS designs and the ability to standardize on fewer SUS designs all contribute to lower the total cost of using SUS to support your bioprocess.

To learn more about how genderless connectors can lead to more flexibility, faster changeovers and reduced costs, read the recent CPC white paper, “The Path to Genderless Connectors.”

Qosina offers a comprehensive line of stock components for single-use systems including an extensive line of aseptic genderless connectors to give you sterile, high-quality single-use connections every time.